No. Your e-cig automatically activates when you draw air through it like you would with a tobacco cigarette. Once the intelligent battery senses air movement, it turns on.
This is indicated by the LED on the the e-cig, near where the cartridge connection point. When you are not using your White Cloud e-cigarette, it goes into standby mode and preserves its battery life.
This means that there is no on/off switch to worry about! Unless you purchased one of our Button Activated Cirrus 3X batteries. If that's the case, please have a look at this article for Button Activated Cirrus 3X battery instructions.